Advancing Research, Improving Lives
PRIME Trials conducts Phase I–IV clinical trials across multiple therapeutic areas. Your participation helps bring safer, more effective treatments to everyone.
Why Prime
Because patient safety and data integrity come first.
We balance the exacting precision of Phase I–IV trials with genuine, empathetic care — so participating feels safe, understood, and meaningful.
Safety first
Every trial follows strict FDA and IRB protocols. Your wellbeing is monitored at every visit.
Cutting-edge science
We partner with leading pharmaceutical and device companies on the newest therapies.
Human-centric care
Dedicated coordinators guide you through every step — no medical jargon, just support.
Flexible visits
Evening and weekend appointments across three sites, with compensated participation.
Therapeutic Areas
Research across the conditions that matter most
Explore our active therapeutic areas. Select one to see the trials currently enrolling.
Now Enrolling
Active studies seeking participants
One-Time Injection for Geographic Atrophy Due to Dry AMD of the Eye
Evaluating the efficacy, safety, and tolerability of an investigational one-time gene therapy given as a single injection under the retina in adults with geographic atrophy (GA) secondary to dry age-related macular degeneration (AMD). Participants are randomly assigned to receive the investigational therapy or to be followed without treatment, with regular eye exams and imaging over 12 months. Participants in the untreated group may be offered the chance to receive the therapy after the study ends. Participation is voluntary. Transportation to and from study visits is always provided.
Type 1 Diabetes Research Study (Children & Teens Under 18)
Help advance type 1 diabetes research. Children and teens under 18 are invited to take part in a blood sample collection study at our Houston, TX site. Participation is voluntary, and we pay for your Uber to and from the visit. Compensation for gas and time: up to $150. To learn more, text “INFO” to (281) 220-9306.
Pediatric Blood Specimen Collection (Ages 2–5)
Healthy boys and girls, ages 2–5 years old, are needed for blood specimen collections. Choosing to donate is optional. A patient stipend is provided. Donating blood or other samples for research may help find a cure or preventive measure for various diseases and conditions, and lead to improved methods of diagnosis and treatment. Participating in research is a simple way of playing an active role in your own health while also helping others.
Our Team
Led by physicians who care
Ophthalmology
Jaafar Fadl El-Annan, M.D., M.D.
Principal Investigator
Board-certified ophthalmologist and fellowship-trained vitreoretinal surgeon with extensive experience in medical and surgical retina, academic ophthalmology, translational research, and clinical investigation. President of Annan Retina Eye Center and Clinical Associate Professor at Baylor College of Medicine, The University of Texas Medical Branch, and MD Anderson Cancer Center.
Cardiology
Alexander Butkevich, MD
Principal Investigator
Dr. Alexander Butkevich is a board-certified cardiologist specializing in cardiovascular disease and advanced heart failure and transplant cardiology. He brings nearly two decades of private-practice experience in general cardiology, cardiac transplantation, mechanical circulatory support, and the management of complex cardiovascular conditions. His research experience spans Phase II and Phase III studies involving heart failure, myocardial infarction, coronary artery disease, atrial fibrillation, hypertension, dyslipidemia, and transthyretin amyloid cardiomyopathy.
Psychiatry
Wafaa Farag, MD
Principal Investigator
Dr. Wafaa Farag is a board-certified psychiatrist with more than 25 years of experience treating children, adolescents, and adults in outpatient, inpatient, and emergency settings. Her clinical research experience includes Phase II and Phase III studies in major depressive disorder, bipolar disorder, schizophrenia, post-traumatic stress disorder, generalized anxiety disorder, ADHD, and insomnia. At Prime Research Institute, she provides medical oversight, ensures protocol adherence, and supports the safe and ethical participation of research subjects.
Our Locations
Find a site near you
PRIME Trials — Pearland (Smith Ranch)
2743 Smith Ranch Rd, Ste 1001, Pearland, TX 77584
A PRIME Trials clinical site offering Phase I–IV trials across our therapeutic areas.
Free on-site parking available.
Accessible by car and local transit.
PRIME Trials — Houston
2020 Southwest Fwy, #205, Houston, TX 77098
A PRIME Trials clinical site offering Phase I–IV trials across our therapeutic areas.
Free on-site parking available.
Accessible by car and local transit.
PRIME Trials — Pearland (Shadow Creek)
12234 Shadow Creek Pkwy, #6106, Pearland, TX 77584
A PRIME Trials clinical site offering Phase I–IV trials across our therapeutic areas.
Free on-site parking available.
Accessible by car and local transit.
Patient Resources
Guides to help you participate with confidence
Understanding clinical research makes participation easier. Start with these plain-language guides.
Getting Started
Joining a Clinical Research Study: What to Expect
A step-by-step walkthrough of the clinical trial journey — from your first inquiry through prescreening, informed consent, and study visits.
Read articleParticipant Rights
Your Rights as a Research Participant
Understanding voluntary participation, your right to ask questions, and how to withdraw from a study at any time.
Read articleCompensation
Clinical Study Compensation: Common Questions Answered
Why clinical study compensation varies, what it typically covers, and where to find study-specific details.
Read articleBe part of the next breakthrough.
Join our database and we will notify you when a study matches your profile — or browse active trials today.