Advancing Research, Improving Lives
Prime Research Institute conducts Phase I–IV clinical trials across multiple therapeutic areas. Your participation helps bring safer, more effective treatments to everyone.
Why Prime
Because patient safety and data integrity come first.
We balance the exacting precision of Phase I–IV trials with genuine, empathetic care — so participating feels safe, understood, and meaningful.
Safety first
Every trial follows strict FDA and IRB protocols. Your wellbeing is monitored at every visit.
Cutting-edge science
We partner with leading pharmaceutical and device companies on the newest therapies.
Human-centric care
Dedicated coordinators guide you through every step — no medical jargon, just support.
Flexible visits
Evening and weekend appointments across three sites, with compensated participation.
Therapeutic Areas
Research across the conditions that matter most
Explore our active therapeutic areas. Select one to see the trials currently enrolling.
Now Enrolling
Active studies seeking participants
Investigational Treatment for Moderate-to-Severe Dry Eye Disease
Evaluating the safety and symptom relief of an investigational eye drop applied twice daily in adults with moderate-to-severe dry eye disease.
Adjunctive Treatment for Major Depressive Disorder
Evaluating an investigational adjunctive therapy for adults with major depressive disorder who have had an inadequate response to antidepressant treatment.
A Study of a Novel PCSK9 Inhibitor in Adults with High Cholesterol
Evaluating the safety and cholesterol-lowering effect of an investigational PCSK9 inhibitor taken once monthly in adults with elevated LDL-C despite statin therapy.
Our Team
Led by physicians who care
Cardiology
Alexander Butkevich, MD
Principal Investigator
Dr. Alexander Butkevich is a board-certified cardiologist specializing in cardiovascular disease and advanced heart failure and transplant cardiology. He brings nearly two decades of private-practice experience in general cardiology, cardiac transplantation, mechanical circulatory support, and the management of complex cardiovascular conditions. His research experience spans Phase II and Phase III studies involving heart failure, myocardial infarction, coronary artery disease, atrial fibrillation, hypertension, dyslipidemia, and transthyretin amyloid cardiomyopathy.
Psychiatry
Wafaa Farag, MD
Principal Investigator
Dr. Wafaa Farag is a board-certified psychiatrist with more than 25 years of experience treating children, adolescents, and adults in outpatient, inpatient, and emergency settings. Her clinical research experience includes Phase II and Phase III studies in major depressive disorder, bipolar disorder, schizophrenia, post-traumatic stress disorder, generalized anxiety disorder, ADHD, and insomnia. At Prime Research Institute, she provides medical oversight, ensures protocol adherence, and supports the safe and ethical participation of research subjects.
Family Medicine and Pediatrics
Indira Maharaj-Mikiel, MD
Principal Investigator
Dr. Indira Maharaj-Mikiel is a board-certified family medicine physician and obesity medicine diplomate with extensive experience across primary care, urgent care, inpatient medicine, preventive health, and metabolic care. As a Principal Investigator, she provides medical oversight, participant-safety review, protocol supervision, and recruitment support for Phase II and Phase III clinical trials, including studies involving adult and pediatric populations. Her clinical breadth and research background support studies across family medicine, immunization, obesity, diabetes, cardiovascular health, and preventive care.
Our Locations
Find a site near you
Prime Research Institute — Pearland (Smith Ranch)
2743 Smith Ranch Rd, Ste 1001, Pearland, TX 77584
A Prime Research Institute clinical site offering Phase I–IV trials across our therapeutic areas.
Free on-site parking available.
Accessible by car and local transit.
Prime Research Institute — Houston
2020 Southwest Fwy, #205, Houston, TX 77098
A Prime Research Institute clinical site offering Phase I–IV trials across our therapeutic areas.
Free on-site parking available.
Accessible by car and local transit.
Prime Research Institute — Pearland (Shadow Creek)
12234 Shadow Creek Pkwy, #6106, Pearland, TX 77584
A Prime Research Institute clinical site offering Phase I–IV trials across our therapeutic areas.
Free on-site parking available.
Accessible by car and local transit.
Be part of the next breakthrough.
Join our database and we will notify you when a study matches your profile — or browse active trials today.
